Diisopropyl Ether → HCID 59750456, compound

HRID 499631Notes

Reaction equation

HRID 499631 reaction equation
[O:1]=[C:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[S:5][C:4]([C:12]2[N:17]=[CH:16][C:15]([CH2:18][CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])=[CH:14][CH:13]=2)=[N:3]1.C(OC(C)C)(C)C>FC(F)(F)C(O)=O>[O:1]=[C:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[S:5][C:4]([C:12]2[N:17]=[CH:16][C:15]([CH2:18][CH2:19][C:20]([OH:22])=[O:21])=[CH:14][CH:13]=2)=[N:3]1

Participants

4

Reactant 2

HCID 7914Diisopropyl EtherHCID 22939492HCID 22939492, compound

Product 1

HCID 59750456HCID 59750456, compoundYield 68.6%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

tert-Butyl 3-[6-(4-oxo-4H-1,3-benzothiazin-2-yl)-3-pyridyl]propanoate (0.21 g, 0.56 mmol) was dissolved in trifluoroacetic acid (5 ml), and the mixture was stirred at room temperature for 0.5 hr. Diisopropyl ether was added to the reaction mixture to give crystals, which were recrystallized from ethanol to give the titled compound (0.12 g, 68%) as white crystals.

Workup

  1. customto give crystals, which
  2. customwere recrystallized from ethanol

Sources & evidence

ORD record
ord-597aa1e036e74247ae20ffcb6a1fcdbe
Source dataset
uspto-grants-2010_08
Patent number
US07767665B2

Reaction notes

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