Diisopropyl Ether → HCID 59750148, compound

HRID 499647Notes

Reaction equation

HRID 499647 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[C:9]([CH2:11][CH2:12][C:13]([O:15]C(C)(C)C)=[O:14])[CH:8]=[C:7]([C:20]2[S:21][C:22]3[CH:30]=[CH:29][CH:28]=[CH:27][C:23]=3[C:24](=[O:26])[N:25]=2)[N:6]=1)(=[O:4])=[O:3].C(OC(C)C)(C)C>FC(F)(F)C(O)=O>[CH3:1][S:2]([C:5]1[CH:10]=[C:9]([CH2:11][CH2:12][C:13]([OH:15])=[O:14])[CH:8]=[C:7]([C:20]2[S:21][C:22]3[CH:30]=[CH:29][CH:28]=[CH:27][C:23]=3[C:24](=[O:26])[N:25]=2)[N:6]=1)(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 7914Diisopropyl EtherHCID 22939524HCID 22939524, compound

Product 1

HCID 59750148HCID 59750148, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

tert-Butyl 3-[2-(methylsulfonyl)-6-(4-oxo-4H-1,3-benzothiazin-2-yl)-4-pyridyl]propanoate (0.20 g, 0.45 mmol) was dissolved in trifluoroacetic acid (5 ml), and the mixture was stirred at room temperature for 0.5 hr. Diisopropyl ether was combined with the reaction mixture to give precipitates, which were recrystallized from ethanol to give the titled compound (0.11 g, 63%) as pale yellow crystals.

Workup

  1. customto give
  2. customprecipitates
  3. customwhich were recrystallized from ethanol

Sources & evidence

ORD record
ord-ed67dcf315ef47a887dd62b634e8a5f7
Source dataset
uspto-grants-2010_08
Patent number
US07767665B2

Reaction notes

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