Hydrochloric Acid → HCID 66887928, compound

HRID 499710Notes

Reaction equation

HRID 499710 reaction equation
[CH3:1][C:2]([C:8]1[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=1)([CH3:7])[C:3]([O:5][CH3:6])=[O:4].[ClH:14]>CO.[Pt](=O)=O>[ClH:14].[CH3:7][C:2]([CH:8]1[CH2:13][CH2:12][CH2:11][NH:10][CH2:9]1)([CH3:1])[C:3]([O:5][CH3:6])=[O:4]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 54537815Methyl 2-methyl-2-pyridin-3-ylpropionate

Product 1

HCID 66887928HCID 66887928, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 345198Adams' catalystSolvent

Procedure

0.115 g of methyl 2-methyl-2-pyridin-3-ylpropionate (CAS 476429-23-9) is dissolved in an autoclave in 5 ml of methanol. The solution is admixed with 0.35 ml of 1.2M HCl in methanol and 0.012 g of platinum(IV) oxide, and the reaction mixture is hydrogenated at 4 bar and 23° over 46 hours. The catalyst is filtered off through Hyflo and the filtrate is concentrated by evaporation to give the crude title compound which is used directly in the next step.

Workup

  1. filtrationThe catalyst is filtered off through Hyflo
  2. concentrationthe filtrate is concentrated by evaporation

Sources & evidence

ORD record
ord-0cb210c0478044a58a8b6303eba04561
Source dataset
uspto-grants-2010_08
Patent number
US07767690B2

Reaction notes

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