Hydrochloric Acid → HCID 178474958, compound

HRID 499713Notes

Reaction equation

HRID 499713 reaction equation
C[O:2][C:3](=[O:17])[C:4]([C@H:7]1[CH2:12][CH2:11][C@H:10]([NH:13][C:14](=[O:16])[CH3:15])[CH2:9][CH2:8]1)([CH3:6])[CH3:5].[OH-].[Li+].Cl>CO>[C:14]([NH:13][C@H:10]1[CH2:11][CH2:12][C@H:7]([C:4]([CH3:6])([CH3:5])[C:3]([OH:17])=[O:2])[CH2:8][CH2:9]1)(=[O:16])[CH3:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 178500374HCID 178500374, compound

Product 1

HCID 178474958HCID 178474958, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.200 g of trans-2-(4-acetylamino-cyclohexyl)-2-methyl-propionic acid methyl ester are dissolved in 4 ml of methanol. 4 ml of a 1M aqueous lithium hydroxide solution are added and the mixture is stirred for 16 hours at room temperature. The reaction mixture is neutralised with 1M HCl and extracted with ethyl acetate (3×50 ml)—the combined organic phases are concentrated by evaporation. The title compound is identified from the residue by means of flash chromatography (SiO2 60 F) based on its Rf value.

Workup

  1. extractionextracted with ethyl acetate (3×50 ml)—the combined organic phases
  2. concentrationare concentrated by evaporation

Sources & evidence

ORD record
ord-505272428e4f4d3ab16e1025876720c9
Source dataset
uspto-grants-2010_08
Patent number
US07767690B2

Reaction notes

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