反应详情

5-Chlorothiophene-2-carbonyl chloride (7.61 g, 42 mmol) is added dropwise to an ice-cooled solution of 2.63 ml (35 mmol) of allylamine in 14.2 ml of absolute pyridine and 14.2 ml of absolute THF. The ice cooling is removed and the mixture is stirred at room temperature for 3 h before being concentrated in vacuo. Water is added to the residue, and the solid is filtered off. The crude product is purified by flash chromatography on silica gel (dichloromethane).

1. customThe ice cooling is removed
2. concentrationbefore being concentrated in vacuo
3. additionWater is added to the residue
4. filtrationthe solid is filtered off
5. customThe crude product is purified by flash chromatography on silica gel (dichloromethane)