Water → N-((1-(4-iodophenyl)-1H-imidazol-4-yl)methyl)-1H-indole-6-carboxamide

HRID 499791Notes

Reaction equation

HRID 499791 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]([OH:12])=O)[CH:8]=2)[CH:3]=[CH:2]1.[NH2:13][CH2:14][C:15]1[N:16]=[CH:17][N:18]([C:20]2[CH:25]=[CH:24][C:23]([I:26])=[CH:22][CH:21]=2)[CH:19]=1.F[P-](F)(F)(F)(F)F.N1(O[P+](N(C)C)(N(C)C)N(C)C)C2C=CC=CC=2N=N1.O>CN(C=O)C.CCOC(C)=O>[I:26][C:23]1[CH:22]=[CH:21][C:20]([N:18]2[CH:19]=[C:15]([CH2:14][NH:13][C:10]([C:7]3[CH:8]=[C:9]4[C:4]([CH:3]=[CH:2][NH:1]4)=[CH:5][CH:6]=3)=[O:12])[N:16]=[CH:17]2)=[CH:25][CH:24]=1

Participants

7

Reactant 4

HCID 962WaterHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 5952301H-indole-6-carboxylic acidHCID 592601094-Aminomethyl 1-(4-iodophenyl)imidazole

Product 1

HCID 66974184N-((1-(4-iodophenyl)-1H-imidazol-4-yl)methyl)-1H-indole-6-carboxamide

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of indole-6-carboxylic acid (85 mg, 0.528 mmol), 4-aminomethyl 1-(4-iodophenyl)imidazole I-2 prepared in Example 1 (136 mg, 0.455 mmol) and TEA (0.150 mL, 1.08 mmol) in DMF (4 mL), BOP (280 mg, 0.633 mmol) was added. After the mixture was stirred at room temperature overnight, water and EtOAc were added. The organic layer was separated, washed with 5% aq. NaHCO3, dried over Na2SO4, concentrated in vacuo to give N-((1-(4-iodophenyl)-1H-imidazol-4-yl)methyl)-1H-indole-6-carboxamide as a crude sample, which was used in the next reaction without further purification. MS 443.0 (M+H).

Workup

  1. additionwas added
  2. customThe organic layer was separated
  3. washwashed with 5% aq. NaHCO3
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-105163e648ef416abcc79d9b6b2e9b1b
Source dataset
uspto-grants-2010_08
Patent number
US07767697B2

Reaction notes

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