Hydrochloric Acid → HCID 23116447, compound

HRID 499892Notes

Reaction equation

[CH3:1][N:2]([CH3:33])[CH2:3][CH2:4][N:5]([CH2:29][CH2:30][O:31][CH3:32])[C:6](=[O:28])[CH2:7][C:8]1[C:13]([C:14](=[O:23])[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[C:12]([OH:24])[CH:11]=[C:10]([OH:25])[C:9]=1[CH2:26][CH3:27].[ClH:34]>C(O)C>[ClH:34].[CH3:33][N:2]([CH3:1])[CH2:3][CH2:4][N:5]([CH2:29][CH2:30][O:31][CH3:32])[C:6](=[O:28])[CH2:7][C:8]1[C:13]([C:14](=[O:23])[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[C:12]([OH:24])[CH:11]=[C:10]([OH:25])[C:9]=1[CH2:26][CH3:27]

Participants

Conditions

Temperature: 4 °C

Procedure

Compound 113 (0.6172 g, 1.346 mmol) obtained in Example 112 was dissolved in ethanol (11 mL). The resulting solution was cooled to 4° C., and a 1.0 mol/L solution of hydrogen chloride in ethanol (1.5 mL) was added thereto, followed by stirring for 20 minutes. The reaction mixture was concentrated under reduced pressure to obtain a quantitative yield of Compound 142.

Workup

concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record: ord-9b870ad6da9d491ab1b38eb97fcff4a0
Source dataset: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07767693B2

Reaction notes

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