反应详情

温度

55 °C

25.7 mg (0.05 mmol) of N-(2-chloroethyl)-4-({[(4-chloro-2-methylphenyl)amino]carbonyl}amino)-1-[4-(trifluoromethyl)benzyl]-1H-imidazole-2-carboxamide (Example 21A) are dissolved in 200 μl of a 2 molar solution of dimethylamine in THF, and 7.5 mg (0.05 mmol) of sodium iodide are added. The reaction mixture is stirred in a tightly closed reaction vessel at 55° C. for 16 h. The reaction solution is then evaporated in vacuo, and the residue from evaporation is dissolved in DMSO, filtered and purified by preparative HPLC (Method 10).

1. additionare added
2. customThe reaction solution is then evaporated in vacuo
3. customthe residue from evaporation
4. dissolutionis dissolved in DMSO
5. filtrationfiltered
6. custompurified by preparative HPLC (Method 10)