Hydrochloric Acid → N,N-Dimethyl-L-valinamide--hydrogen chloride (1/1)

HRID 500177Notes

Reaction equation

HRID 500177 reaction equation
[CH3:1][N:2]([CH3:17])[C:3]([C@@H:5]([NH:9]C(=O)OC(C)(C)C)[CH:6]([CH3:8])[CH3:7])=[O:4].[ClH:18]>O1CCOCC1>[ClH:18].[NH2:9][C@@H:5]([CH:6]([CH3:8])[CH3:7])[C:3]([N:2]([CH3:17])[CH3:1])=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10944665HCID 10944665, compound

Product 1

HCID 56831841N,N-Dimethyl-L-valinamide--hydrogen chloride (1/1)

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl (1S)-1-[(dimethylamino)carbonyl]-2-methylpropylcarbamate (131 mg) was treated with 4M of hydrogen chloride in 1,4-dioxane (1.0 mL) at RT for 2 h. The solvent was evaporated under reduced pressure. The residue was dried to give the desired product (96 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customThe residue was dried

Sources & evidence

ORD record
ord-d0baaf77c7bb4ae8a90fb501b07ccc25
Source dataset
uspto-grants-2010_08
Patent number
US07767675B2

Reaction notes

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