Hydrochloric Acid → HCID 67224707, compound

HRID 500211Notes

Reaction equation

HRID 500211 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]3([C:14]4[N:18]5[N:19]=[C:20]([C:23]6[CH:28]=[CH:27][C:26]([C:29]7[CH2:30][CH2:31][N:32](C(OC(C)(C)C)=O)[CH2:33][CH:34]=7)=[CH:25][CH:24]=6)[CH:21]=[N:22][C:17]5=[N:16][CH:15]=4)[CH2:13][CH2:12]3)=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[ClH:42]>O1CCOCC1>[ClH:42].[NH:32]1[CH2:33][CH:34]=[C:29]([C:26]2[CH:25]=[CH:24][C:23]([C:20]3[CH:21]=[N:22][C:17]4[N:18]([C:14]([C:11]5([C:7]6[CH:6]=[C:5]7[C:10](=[CH:9][CH:8]=6)[N:1]=[CH:2][CH:3]=[CH:4]7)[CH2:13][CH2:12]5)=[CH:15][N:16]=4)[N:19]=3)=[CH:28][CH:27]=2)[CH2:30][CH2:31]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68461756HCID 68461756, compound

Product 1

HCID 67224707HCID 67224707, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 4-{4-[7-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-b][1,2,4]triazin-2-yl]phenyl}-3,6-dihydropyridine-1(2H)-carboxylate (36.0 mg, 0.0661 mmol) was dissolved in 4M of hydrogen chloride in 1,4-dioxane (5.0 mL) and stirred at RT for 2 h. The volatiles were removed under vacuum and the residue was azeotropically washed with acetonitrile. The crude material was used in the next step. LCMS: (M+H)=445.0.

Workup

  1. customThe volatiles were removed under vacuum
  2. washthe residue was azeotropically washed with acetonitrile

Sources & evidence

ORD record
ord-dfbbf9288b14474fb2a93e7f522c3e02
Source dataset
uspto-grants-2010_08
Patent number
US07767675B2

Reaction notes

Loading…