Hydrochloric Acid → 4-(Methoxymethyl)oxan-4-amine hydrochloride

HRID 500226Notes

Reaction equation

HRID 500226 reaction equation
C(OC(=O)[NH:7][C:8]1([CH2:14][O:15][CH3:16])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)(C)(C)C.[ClH:18]>CCOC(C)=O.O1CCOCC1>[ClH:18].[CH3:16][O:15][CH2:14][C:8]1([NH2:7])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 90902949tert-butyl[4-(methoxymethyl)tetrahydro-2H-pyran-4-yl]carbamate

Product 1

HCID 672251054-(Methoxymethyl)oxan-4-amine hydrochloride

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl[4-(methoxymethyl)tetrahydro-2H-pyran-4-yl]carbamate (0.45 g, 0.0018 mol) in EtOAc (0.2 mL) was added 4M of hydrogen chloride in 1,4-dioxane (3 mL) and stirred for 2 h. The volatiles were removed under reduced pressure to give the desired compound which was directly used in next step without further purification. LCMS: (M+H)=146.2.

Workup

  1. customThe volatiles were removed under reduced pressure

Sources & evidence

ORD record
ord-db60052177784752a16881e7063a59d9
Source dataset
uspto-grants-2010_08
Patent number
US07767675B2

Reaction notes

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