Hydrochloric Acid → (2R)-2-aminopropyl dimethylcarbamate hydrochloride

HRID 500228Notes

Reaction equation

HRID 500228 reaction equation
[CH3:1][N:2]([CH3:17])[C:3](=[O:16])[O:4][CH2:5][C@H:6]([NH:8]C(OC(C)(C)C)=O)[CH3:7].[ClH:18]>CCOC(C)=O.O1CCOCC1>[ClH:18].[CH3:1][N:2]([CH3:17])[C:3](=[O:16])[O:4][CH2:5][C@H:6]([NH2:8])[CH3:7]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86621510(2R)-2-[(tert-butoxycarbonyl)amino]propyl dimethylcarbamate

Product 1

HCID 86621511(2R)-2-aminopropyl dimethylcarbamate hydrochloride

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of (2R)-2-[(tert-Butoxycarbonyl)amino]propyl dimethylcarbamate (16.0 mg, 0.0650 mmol) in EtOAc (0.2 mL) was added 4M of hydrogen chloride in 1,4-dioxane (0.5 mL) and stirred for 1 h. The volatiles were removed under reduce pressure to give the desired compound. LCMS: (M+H)=147.1.

Workup

  1. customThe volatiles were removed

Sources & evidence

ORD record
ord-f718874ab4c04897bfc1796e6acec795
Source dataset
uspto-grants-2010_08
Patent number
US07767675B2

Reaction notes

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