HRID500236

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CC(C)(C)OC(=O)[C@@H](NC(=O)c1ccc(-c2cnc3ncc(Cc4ccc5ncccc5c4)n3n2)cc1F)C(C)(C)C

HCID67224374

未命名化合物

PRODUCTS

生成物

HCID6422

未命名化合物

结构：CC(C)(C)[C@H](NC(=O)c1ccc(-c2cnc3ncc(Cc4ccc5ncccc5c4)n3n2)cc1F)C(=O)O

HCID67223955

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Trifluoroacetic acid (1.0 mL, 0.013 mol) was added to a solution of tert-butyl (2S)-2-(2-fluoro-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzoylamino)-3,3-dimethylbutanoate (0.092 g, 0.16 mmol) in methylene chloride (1.0 mL) and stirred at RT for 2 h. The volatiles were removed under reduced pressure to give the desired product as a TFA salt. LCMS: (M+H)=513.4.

WORKUP

后处理

customThe volatiles were removed under reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5a3c904e6a4d4b9780d132027713302c
来源数据集: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07767675B2
来源说明: uspto-grants-2010_08

反应 SMILES

[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:29]=[C:28]([C:30]2[CH:31]=[N:32][C:33]3[N:34]([C:36]([CH2:39][C:40]4[CH:41]=[C:42]5[C:47](=[CH:48][CH:49]=4)[N:46]=[CH:45][CH:44]=[CH:43]5)=[CH:37][N:38]=3)[N:35]=2)[CH:27]=[CH:26][C:10]=1[C:11]([NH:13][C@@H:14]([C:22]([CH3:25])([CH3:24])[CH3:23])[C:15]([O:17]C(C)(C)C)=[O:16])=[O:12]>C(Cl)Cl>[F:8][C:9]1[CH:29]=[C:28]([C:30]2[CH:31]=[N:32][C:33]3[N:34]([C:36]([CH2:39][C:40]4[CH:41]=[C:42]5[C:47](=[CH:48][CH:49]=4)[N:46]=[CH:45][CH:44]=[CH:43]5)=[CH:37][N:38]=3)[N:35]=2)[CH:27]=[CH:26][C:10]=1[C:11]([NH:13][C@@H:14]([C:22]([CH3:25])([CH3:24])[CH3:23])[C:15]([OH:17])=[O:16])=[O:12].[C:3]([OH:5])([C:2]([F:7])([F:6])[F:1])=[O:4]