Triethylamine → HCID 11201612, compound

Temperature

120 °C

To a solution of (R)-3-cyclohexyl-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazine (100 mg, 0.41 mmol) in 1,1,2,2-tetrachloroethane (2.0 ml), was added oxalyl chloride (58 mg, 0.46 mmol) with stirring under a stream of nitrogen. The mixture was heated at 120° C. for 1.5 h. The mixture was cooled to room temperature and triethylamine (46 mg, 0.46 mmol) and (S)-octahydro-2H-pyrido[1,2-a]pyrazine (70 mg, 0.50 mmol) were added. The mixture was stirred at room temperature for 19 h and then partitioned between dichloromethane and water. The aqueous layer was extracted with dichloromethane, and the combined organic layers washed with brine, dried over Na2SO4 and concentrated. The resulting brown oil was purified by flash chromatography eluting with 50% (v/v) ethyl acetate in n-heptane, then 0-17% (v/v) methanol in ethyl acetate to afford the title compound as the free base. Hydrochloride salt formation was achieved by the addition of hydrogen chloride (2 M solution in diethyl ether, 1 ml) to a solution of the free base in diethyl ether (2 ml) and ethanol (2 ml). The solvent was removed in vacuo and the precipitate was dried to afford the title compound (1:1 hydrochloride salt) as a solid (78 mg, 0.18 mmol).

1. temperatureThe mixture was cooled to room temperature
2. stirringThe mixture was stirred at room temperature for 19 h
3. custompartitioned between dichloromethane and water
4. extractionThe aqueous layer was extracted with dichloromethane
5. washthe combined organic layers washed with brine
6. dry with materialdried over Na2SO4
7. concentrationconcentrated
8. customThe resulting brown oil was purified by flash chromatography
9. washeluting with 50% (v/v) ethyl acetate in n-heptane

ORD record

ord-a893d11a2e6c41549cb38ac7bca51448

Source dataset

uspto-grants-2010_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07772227B2