HRID50066

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

结构：Cl.O=C(c1ccccc1)N1CCCC(CCCN2CCC(C(=O)N3CCCC3)CC2)(c2ccc(Cl)c(Cl)c2)C1

HCID22741714

未命名化合物

结构：CCOC(=O)NC1(Cc2ccccc2)CCNCC1.Cc1ccc(S(=O)(=O)O)cc1

HCID22741781

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)NC1(Cc2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1.CCOC(=O)NC1(Cc2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1.Cl.Cl.O

HCID131721654

未命名化合物

收率 83.5%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

This compound is prepared by the procedure described in EXAMPLE 7, starting from 0.5 g of 4-benzyl-4-(ethoxycarbonylamino)piperidine p-toluene-sulfonate, 0.5 g of the compound obtained in step B of EXAMPLE 1 and 0.52 g of K2CO3 in 5 ml of DMF. This gives 0.32 g of the expected product, m.p.=142° C. (dec.).

WORKUP

后处理

customThis compound is prepared by the procedure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b26d300e35994261af3c49659fad30ac
来源数据集: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06710042B2
来源说明: uspto-grants-2004_03

反应 SMILES

C1(C)C=CC(S(O)(=O)=[O:8])=CC=1.[CH2:12]([C:19]1([NH:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[ClH:31].[C:32]([N:40]1[CH2:45][CH2:44][CH2:43][C:42]([C:62]2[CH:67]=[CH:66][C:65]([Cl:68])=[C:64]([Cl:69])[CH:63]=2)([CH2:46][CH2:47][CH2:48]N2CCC(C(N3CCCC3)=O)CC2)[CH2:41]1)(=[O:39])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[OH2:8].[ClH:68].[C:32]([N:40]1[CH2:45][CH2:44][CH2:43][C:42]([CH2:46][CH2:47][CH2:48][N:22]2[CH2:21][CH2:20][C:19]([CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)([NH:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])[CH2:24][CH2:23]2)([C:62]2[CH:67]=[CH:66][C:65]([Cl:68])=[C:64]([Cl:69])[CH:63]=2)[CH2:41]1)(=[O:39])[C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1.[C:32]([N:40]1[CH2:45][CH2:44][CH2:43][C:42]([C:62]2[CH:67]=[CH:66][C:65]([Cl:68])=[C:64]([Cl:69])[CH:63]=2)([CH2:46][CH2:47][CH2:48][N:22]2[CH2:21][CH2:20][C:19]([NH:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])([CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:24][CH2:23]2)[CH2:41]1)(=[O:39])[C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1.[ClH:31]