Pyrazole → N-(4-(2-(1H-Pyrazol-1-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide

HRID 500888Notes

Reaction equation

HRID 500888 reaction equation
C[C:2]1[CH:3]=[N:4][N:5]([C:7]2[S:15][C:14]3[C:9](=[N:10][CH:11]=[CH:12][C:13]=3[O:16][C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24]([NH:26][C:27](=[O:35])[CH2:28][C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)=[S:25])=[CH:19][CH:18]=3)[CH:8]=2)[CH:6]=1.CC1C=NNC=1.N1C=CC=N1>>[N:5]1([C:7]2[S:15][C:14]3[C:9](=[N:10][CH:11]=[CH:12][C:13]=3[O:16][C:17]3[CH:18]=[CH:19][C:20]([NH:23][C:24]([NH:26][C:27](=[O:35])[CH2:28][C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)=[S:25])=[CH:21][CH:22]=3)[CH:8]=2)[CH:6]=[CH:2][CH:3]=[N:4]1

Participants

4

Reactant 3

HCID 1048PyrazoleHCID 34064-MethylpyrazoleHCID 86604190N-(4-(2-(4-Methyl-1H-pyrazol-1-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide

Product 1

HCID 86604191N-(4-(2-(1H-Pyrazol-1-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide

Procedure

Following the procedures described above for the synthesis of compound 258a (example 215, scheme 58) but replacing 4-methyl-1H-pyrazole in the step 1 with 1H-pyrazole, title compound 258b was obtained. Characterization of 258b is provided in the table 23.

Sources & evidence

ORD record
ord-49e7b332fefd4893821c1fc34710d667
Source dataset
uspto-grants-2010_08
Patent number
US07772247B2

Reaction notes

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