Dimethylformamide → HCID 22024515, compound

HRID 500987Notes

Reaction equation

HRID 500987 reaction equation
[Cl:1][C:2]1[C:3]2[N:4]([CH:8]=[C:9]([CH2:11][CH3:12])[N:10]=2)[CH:5]=[CH:6][N:7]=1.P(Cl)(Cl)(Cl)=O.CN(C)[CH:20]=[O:21]>>[Cl:1][C:2]1[C:3]2[N:4]([C:8]([CH:20]=[O:21])=[C:9]([CH2:11][CH3:12])[N:10]=2)[CH:5]=[CH:6][N:7]=1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 120740798-Chloro-2-ethylimidazo[1,2-a]pyrazine

Product 1

HCID 22024515HCID 22024515, compound

Conditions

Temperature
90 °C

Procedure

8-Chloro-2-ethylimidazo[1,2-a]pyrazine (600 mg, 3.3 mmol) was dissolved in N,N-dimethylformamide (3.3 mL), phosphorus oxychloride (1.2 mL, 13.2 mmol) was added dropwise at room temperature, and the mixture was heated under stirring at 90° C. for 2 hours. After being allowed to cool, the reaction mixture was poured into ice and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and evaporated to give the title compound (472 mg) as white crystals.

Workup

  1. temperaturethe mixture was heated
  2. temperatureto cool
  3. additionthe reaction mixture was poured into ice
  4. extractionextracted with ethyl acetate
  5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  6. customevaporated

Sources & evidence

ORD record
ord-b2cae1935af54bd7b72b2b061af7a663
Source dataset
uspto-grants-2010_08
Patent number
US07772249B2

Reaction notes

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