反应详情

410 mg of tert-butyl cyclopropylsulfamoylcarbamate, 150 μl of 1,2-dibromoethane and 719 mg of K2CO3 were boiled under reflux in 6 ml of anhydrous acetone for 9 hours. The reaction mixture was left to stand at RT for 15 hours. Then 20 mg of tetrabutylammonium iodide were added, and the mixture was boiled under reflux for 9 hours. It was then diluted with 100 ml of EA and washed twice with 10 ml of water each time. After drying over Na2SO4, the solvent was removed in vacuo. 400 mg of a colorless oil were obtained.

1. waitThe reaction mixture was left
2. temperatureunder reflux for 9 hours
3. washwashed twice with 10 ml of water each time
4. dry with materialAfter drying over Na2SO4
5. customthe solvent was removed in vacuo