4-Pyridinecarboxaldehyde → HCID 136059627, compound

HRID 501457Notes

Reaction equation

HRID 501457 reaction equation
[NH2:1][C:2]1[C:3](=[O:10])[N:4]([CH3:9])[N:5]=[CH:6][C:7]=1[NH2:8].[N:11]1[CH:16]=[CH:15][C:14]([CH:17]=O)=[CH:13][CH:12]=1>[N+](C1C=CC=CC=1)([O-])=O>[CH3:9][N:4]1[C:3](=[O:10])[C:2]2[N:1]=[C:17]([C:14]3[CH:15]=[CH:16][N:11]=[CH:12][CH:13]=3)[NH:8][C:7]=2[CH:6]=[N:5]1

Participants

4

Reactant 2

HCID 133894-PyridinecarboxaldehydeHCID 127272614,5-Diamino-2-methylpyridazin-3(2H)-one

Product 1

HCID 136059627HCID 136059627, compoundYield 42%

Reagents, catalysts & solvents 1

HCID 7416NitrobenzeneSolvent

Conditions

Temperature
190 °C

Procedure

0.560 g of 4,5-diamino-2-methyl-2H-pyridazin-3-one and 0.535 g of 4-pyridinecarbaldehyde were added to 10 ml of nitrobenzene, and the mixture was heated at 190° C. under a nitrogen atmosphere for three hours. The reaction solution was cooled down, and the precipitate was collected by filtration to give 0.381 g of the title compound.

Workup

  1. temperatureThe reaction solution was cooled down
  2. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-4d8f31411cdd4040a7147e2c401d4e14
Source dataset
uspto-grants-2010_08
Patent number
US07772226B2

Reaction notes

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