Acetone → HCID 57472860, compound

HRID 501458Notes

Reaction equation

[CH2:1]([N:5]1[C:13]2[C:12](=[O:14])[N:11]([CH3:15])[N:10]=[CH:9][C:8]=2[N:7]=[C:6]1[C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1)[C:2]#[C:3][CH3:4].[CH3:22][O:23][C:24]1[CH:31]=[CH:30][C:27]([CH2:28][Cl:29])=[CH:26][CH:25]=1.CN(C)C=O.CC(C)=O>C(OCC)C>[Cl-:29].[CH2:1]([N:5]1[C:13]2[C:12](=[O:14])[N:11]([CH3:15])[N:10]=[CH:9][C:8]=2[N:7]=[C:6]1[C:16]1[CH:21]=[CH:20][N+:19]([CH2:28][C:27]2[CH:30]=[CH:31][C:24]([O:23][CH3:22])=[CH:25][CH:26]=2)=[CH:18][CH:17]=1)[C:2]#[C:3][CH3:4]

Participants

Conditions

Temperature: 65 °C

Procedure

0.045 g of 3-(2-butynyl)-5-methyl-2-(pyridin-4-yl)-3,5-dihydroimidazo[4,5-d]pyridazin-4-one and 0.060 μl of p-methoxybenzyl chloride were added to 0.100 ml of N,N-dimethylformamide, and the mixture was stirred at 65° C. under a nitrogen atmosphere for 4 hours. The reaction solution was cooled down, and 1 ml of acetone and 1 ml of diethyl ether were added thereto. The precipitate was collected by filtration to give 0.060 g of the title compound.

Workup

temperatureThe reaction solution was cooled down
filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record: ord-0dce1d1d1bbc4f9ab44732d77271fd9b
Source dataset: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07772226B2

Reaction notes

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