Methane → HCID 68457450, compound

HRID 501491Notes

Reaction equation

HRID 501491 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([S:16]([N:19]3[CH:23]([C:24]([OH:26])=[O:25])[CH2:22][CH:21]4[CH2:27][CH2:28][CH2:29][CH:20]34)(=[O:18])=[O:17])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)([O-])=O.C>CN(C=O)C.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:11]=[CH:12][C:13]([S:16]([N:19]3[CH:23]([C:24]([OH:26])=[O:25])[CH2:22][CH:21]4[CH2:27][CH2:28][CH2:29][CH:20]34)(=[O:18])=[O:17])=[CH:14][CH:15]=2)=[CH:6][CH:5]=1

Participants

5

Reactant 2

HCID 297MethaneHCID 68458164HCID 68458164, compound

Product 1

HCID 68457450HCID 68457450, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 6228DimethylformamideSolvent

Procedure

1 g of 1-(4′-nitrobiphenyl-4-sulfonyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid (27) was dissolved in 15 ml of DMF, after which 0.1 g of hydrogenation catalyst (10% Pd on active charcoal) was added and the starting compound was quantitatively hydrogenated within 2 h. After the solvent had been removed, the crude product was purified chromatographically.

Workup

  1. customAfter the solvent had been removed
  2. customthe crude product was purified chromatographically

Sources & evidence

ORD record
ord-0400f56188354139b8dcea45c75c6294
Source dataset
uspto-grants-2010_08
Patent number
US07772270B2

Reaction notes

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