反应详情

A suspension of commercially available 4-nitroindane (10 g, 61.3 mmol) and 10% Pd/C (1 g) in MeOH (200 mL) was stirred vigorously under an atmosphere of hydrogen overnight at rt. The reaction was filtered through a pad of Celite® and concentrated, and residual solvent was removed by combining the reaction with toluene followed by evaporation. The crude reaction was taken up in pyridine (100 mL), and Ac2O (20 mL) was added and the reaction stirred for 16 h at rt. The reaction was evaporated and the crude product was purified by flash chromatography (5% MeOH in EtOAc/hexane (1:1) to give the title compound (9.12 g).

1. filtrationThe reaction was filtered through a pad of Celite®
2. concentrationconcentrated
3. customresidual solvent was removed
4. customthe reaction with toluene
5. customfollowed by evaporation
6. customThe crude reaction
7. stirringthe reaction stirred for 16 h at rt
8. customThe reaction was evaporated
9. customthe crude product was purified by flash chromatography (5% MeOH in EtOAc/hexane (1:1)