反应详情

Intermediate 80E (36 mg, 0.073 mmol) was dissolved in DCM (900 μL) and TFA (100 μL) was added. The mixture was stirred at rt for 10 h. The reaction was diluted with EtOAc, washed with saturated sodium bicarbonate solution (3×5 mL), brine (5 mL), dried (MgSO4), filtered and concentrated to give the title compound 80F (27 mg): MS (ES) m/z 394.5 [M+H]+.

1. washwashed with saturated sodium bicarbonate solution (3×5 mL), brine (5 mL)
2. dry with materialdried (MgSO4)
3. filtrationfiltered
4. concentrationconcentrated