Hydrochloric Acid → HCID 22465450, compound

HRID 50175Notes

Reaction equation

HRID 50175 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([C:26]4[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=4)([C:20]4[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=4)[OH:19])[CH:16]=3)[N:11]=[C:10]([O:32]C)[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.Cl.[CH2:35]1COCC1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([OH:19])([C:26]4[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=4)[C:20]4[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=4)[CH:16]=3)[N:11]([CH3:35])[C:10](=[O:32])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 22465407HCID 22465407, compound

Product 1

HCID 22465450HCID 22465450, compoundYield 100%

Procedure

Following the same procedure as described in example 1F, [4-(3-chloro-phenyl)-2-methoxy-quinolin-6-yl]-di-pyridin-3-yl-methanol (300 mg, 0.66 mmol) was treated with HCl in aqueous THF to yield the title compound (290 mg, 100% yield).

Sources & evidence

ORD record
ord-672ebb3a38504adca66e6398a2b5a9f6
Source dataset
uspto-grants-2004_03
Patent number
US06710209B2

Reaction notes

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