Hydrochloric Acid → 4-(3-ethoxy-phenyl)-6-(hydroxy-di-pyridin-3-yl-methyl)-1H-quinolin-2-one

HRID 50177Notes

Reaction equation

HRID 50177 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([C:20]([C:28]4[CH:29]=[N:30][CH:31]=[CH:32][CH:33]=4)([C:22]4[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=4)[OH:21])[CH:18]=3)[N:13]=[C:12]([O:34]C)[CH:11]=2)[CH:7]=[CH:8][CH:9]=1)[CH3:2].Cl>C1COCC1>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([C:20]([OH:21])([C:22]4[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=4)[C:28]4[CH:29]=[N:30][CH:31]=[CH:32][CH:33]=4)[CH:18]=3)[NH:13][C:12](=[O:34])[CH:11]=2)[CH:7]=[CH:8][CH:9]=1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22465390[4-(3-Ethoxy-phenyl)-2-methoxy-quinolin-6-yl]-di-pyridin-3-yl-methanol

Product 1

HCID 224654144-(3-ethoxy-phenyl)-6-(hydroxy-di-pyridin-3-yl-methyl)-1H-quinolin-2-oneYield 44.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following the same procedure as described in example 1F, [4-(3-ethoxy-phenyl)-2-methoxy-quinolin-6-yl]-di-pyridin-3-yl-methanol (212 mg, 0.457 mmol) was treated with HCl in aqueous THF to yield the title compound (91 mg, 44.3% yield).

Sources & evidence

ORD record
ord-19887dc558144894847848b5693d0f22
Source dataset
uspto-grants-2004_03
Patent number
US06710209B2

Reaction notes

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