反应详情

36.2 gm Powdered potassium hydroxide was added portion wise to a clear solution of a mixture of 100 gm N-[3-[3-(Dimethylamino)-1-oxo-2-propenyl]phenyl] acetamide and 70 ml ethyl iodide in 1000 ml of dimethyl formamide at 39°-42° C. over 60 min. the reaction mixture was stirred for 6 hrs. after completion, the reaction mixture was quenched in water and extracted in dichloromethane. The dichloromethane layer was washed with water, dried over sodium sulphate and concentrated to get oil, which upon trituration in hexane gave a solid product which was filtered and dried at 40° C. under vacuum to give the title compound.

1. customafter completion, the reaction mixture was quenched in water
2. extractionextracted in dichloromethane
3. washThe dichloromethane layer was washed with water
4. dry with materialdried over sodium sulphate
5. concentrationconcentrated
6. customto get oil, which upon trituration in hexane
7. customgave a solid product which
8. filtrationwas filtered
9. customdried at 40° C. under vacuum