反应详情

4.25 gm of Potassium tert-butoxide was added portion wise to a clear solution of 5 gm N-[3-[3-(Dimethylamino)-1-oxo-2-propenyl]-phenyl] acetamide in 50 ml dimethyl formamide. A solution of 5.25 gm Ethyl iodide in 20 ml dimethyl formamide was added drop wise over 3 hrs. at 35° C.-40° C. The reaction mass was stirred for 6 hrs and then quenched in 300 ml of water and extracted in dichloromethane. The organic layer was washed with water, dried over sodium sulphate and concentrated under vacuum to get oil, which was dissolved in 5 ml dichloromethane and 50 ml hexane was added to precipitate the product. The solids obtained was filtered and washed with hexane and dried in vacuum tray dryer at 35° C. for 6 hrs.

1. customat 35° C.-40° C
2. customquenched in 300 ml of water
3. extractionextracted in dichloromethane
4. washThe organic layer was washed with water
5. dry with materialdried over sodium sulphate
6. concentrationconcentrated under vacuum
7. customto get oil, which
8. customto precipitate the product
9. customThe solids obtained
10. filtrationwas filtered
11. washwashed with hexane
12. customdried in vacuum tray dryer at 35° C. for 6 hrs