反应详情

17.5 gm Sodium methoxide was added portion wise to a clear solution of 50 gm N-[3-[3-(Dimethylamino)-1-oxo-2-propenyl]-phenyl] acetamide and 85 gm ethyl iodide in 500 ml dimethyl formamide. After 6 hrs of stirring at room temperature, the reaction mass was quenched in 5 liters of water and extracted in dichloromethane. The dichloromethane layer was washed with water, dried over sodium sulphate and concentrated under vacuum to get oil, which upon trituration in hexane gave the title product as a solid.

1. customthe reaction mass was quenched in 5 liters of water
2. extractionextracted in dichloromethane
3. washThe dichloromethane layer was washed with water
4. dry with materialdried over sodium sulphate
5. concentrationconcentrated under vacuum
6. customto get oil, which upon trituration in hexane