反应详情

Imidazole (3.3 g) and tert-butyl-diphenylchlorosilane (10.0 g) were added to a solution of (3-bromo-5-fluorophenyl)methanol (5.0 g) in dimethylformamide (50 ml), and the mixture was stirred over night at room temperature. The reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with saturated saline solution and dried over anhydrous magnesium sulfate. After filtration, the solvent was evaporated from the filtrate under reduced pressure to give the residue. The resulting residue was purified by silica gel column chromatography (n-hexane-ethyl acetate) to obtain [(3-bromo-5-fluorobenzyl)oxy](tert-butyl)diphenylsilane (9.5 g).

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with saturated saline solution
3. dry with materialdried over anhydrous magnesium sulfate
4. filtrationAfter filtration
5. customthe solvent was evaporated from the filtrate under reduced pressure
6. customto give the residue
7. customThe resulting residue was purified by silica gel column chromatography (n-hexane-ethyl acetate)