Sodium hydride → tert-Butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate

Temperature

0 °C

Sodium hydride (60% in mineral oil, 4.8 g, 120 mmol) was washed with hexanes and then suspended in N,N-dimethylformamide (100 mL). The mixture was cooled to 0° C. Trimethyl phosphonoacetate (17.0 mL, 111 mmol) was added to the mixture dropwise. The reaction was held at 0° C. for 45 minutes. A solution of N-tert-butoxycarbonyl-4-piperidone (18.5 g, 92.6 mmol) in N,N-dimethylformamide (25 mL) was added to the reaction mixture dropwise. The mixture was held at 0° C. for 1 h and then warmed to room temperature where it was held for 1 h. The reaction was quenched with 1 N hydrochloric acid. The mixture was extracted with diethyl ether (2×). Combined organic layers were washed with water (2×), then brine. The organic layer was dried (magnesium sulfate), filtered, and concentrated in vacuo. The residue was dissolved in 1:1 ethyl acetate/methanol (60 mL). A catalytic amount of palladium (10% on charcoal) was added to the mixture. The reaction vessel was placed on a Parr apparatus, charged with 55 psi of hydrogen, and shaken at room temperature for 18 h. The reaction mixture was removed from the Parr apparatus and filtered. The filtrate was concentrated in vacuo to give the title compound as lightly colored oil in 94% yield. 1H NMR (300 MHz, CDCl3): δ 4.04 (d, J=10.25, 2H), 3.64 (s, 3H), 2.68 (t, J=14.44, 2H), 2.21 (d, J=6.95, 2H), 1.99-1.80 (m, 1H), 1.64 (d, J=13.54, 2H), 1.41 (s, 9H), 1.25-1.03 (m, 2H).

1. waitThe mixture was held at 0° C. for 1 h
2. temperaturewarmed to room temperature where it
3. waitwas held for 1 h
4. customThe reaction was quenched with 1 N hydrochloric acid
5. extractionThe mixture was extracted with diethyl ether (2×)
6. washCombined organic layers were washed with water (2×)
7. dry with materialThe organic layer was dried (magnesium sulfate)
8. filtrationfiltered
9. concentrationconcentrated in vacuo
10. dissolutionThe residue was dissolved in 1:1 ethyl acetate/methanol (60 mL)
11. additionA catalytic amount of palladium (10% on charcoal) was added to the mixture
12. additioncharged with 55 psi of hydrogen
13. customThe reaction mixture was removed from the Parr apparatus
14. filtrationfiltered
15. concentrationThe filtrate was concentrated in vacuo

ORD record

ord-3fd0836713874d5883b824ed9a530593

Source dataset

uspto-grants-2010_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07772244B2