HRID502304

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID3939

Lithium hydroxide anhydrous

HLiO

结构：COC(=O)[C@@H]1CC(Oc2ccccc2)CN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C

HCID54377655

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N1CC(Oc2ccccc2)C[C@H]1C(=O)O)C(C)C

HCID54232766

未命名化合物

收率 49.9%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21881883

Oxolane--water (1/1)

C4H10O2

PROCEDURE

实验过程

Lithium hydroxide (57 mg, 1.37 mmol) was added to a solution of N-Acetyl-tyrosinyl-valinyl-(4-phenoxy)proline methyl ester (360 mg, 0.685 mmol) dissolved in 8 ml of tetrahydrofuran/water (1:1) and stirred at room temperature for 1 hour. The mixture was acidified with 10% hydrochloric acid giving a white precipitate that was collected to give 175 mg of the title compound.

WORKUP

后处理

customwas collected

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8633ab497e4042abbfe78a371d465a1e
来源数据集: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07772366B2
来源说明: uspto-grants-2010_08

反应 SMILES

[OH-].[Li+].C[O:4][C:5](=[O:40])[C@@H:6]1[CH2:10][CH:9]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:8][N:7]1[C:18](=[O:39])[C@H:19]([CH:36]([CH3:38])[CH3:37])[NH:20][C:21](=[O:35])[C@H:22]([CH2:27][C:28]1[CH:33]=[CH:32][C:31]([OH:34])=[CH:30][CH:29]=1)[NH:23][C:24](=[O:26])[CH3:25].Cl>O1CCCC1.O>[C:24]([NH:23][C@H:22]([C:21]([NH:20][C@H:19]([C:18]([N:7]1[CH2:8][CH:9]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:10][C@H:6]1[C:5]([OH:40])=[O:4])=[O:39])[CH:36]([CH3:38])[CH3:37])=[O:35])[CH2:27][C:28]1[CH:29]=[CH:30][C:31]([OH:34])=[CH:32][CH:33]=1)(=[O:26])[CH3:25]