反应详情

To the above synthesized 2-ethoxy-4′-trifluoromethyl-biphenyl-4-carboxylic acid ethyl ester (0.515 g, 1.52 mmol), dissolved in 6 ml of abs. THF, was added drop wise at −10° C. DIBAL-H solution in toluene (3.81 ml 1M, 2.5 eq.). After additional 60 Min. at ambient temperature, the reaction mixture was carefully poured onto crashed ice/dil. HCl-solution, twofold extracted with AcOEt, washed with water, dried over sodium sulfate, and evaporated to dryness. Thereby, 0.359 g of the title alcohol was isolated as white solid, sufficiently pure for the next step.

1. dissolutiondissolved in 6 ml of abs
2. additionat ambient temperature, the reaction mixture was carefully poured
3. extractionHCl-solution, twofold extracted with AcOEt
4. washwashed with water
5. dry with materialdried over sodium sulfate
6. customevaporated to dryness