反应详情

In analogy to the procedure described in example 50k), 2,6-dimethyl-N-piperidin-4-yl-terephthalamic acid [prepared from 4-(4-tert-butoxycarbonyl-3,5-dimethyl-benzoylamino)-piperidine-1-carboxylic acid tert-butyl ester and trifluoroacetic acid in dichloromethane in analogy to the procedure described in example 50i)] was reacted with 3,5-diisopropoxy-benzaldehyde [prepared from 3,5-dihydroxy-benzaldehyde and 2-bromopropane, potassium carbonate in DMF at 60° C. in analogy to the procedure described in example 50e)], sodium cyanoborohydride, N-ethyl-diisopropylamine and acetic acid in ethanol at 50° C. to yield the title compound as light yellow solid. MS: 483.3 (MH+).

1. customat 50° C.