HRID502438

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81531

Diisopropylethylamine

C8H19N

HCID5003444

Sodium cyanotrihydroborate

CH3BNNa

HCID11310605

3,5-diisopropoxybenzaldehyde

C13H18O3

结构：COc1cc(OCC(O)CO)cc(C(=O)NC2CCNCC2)c1.O=C(O)C(F)(F)F

HCID68458548

未命名化合物

PRODUCTS

生成物

结构：COc1cc(OCC(O)CO)cc(C(=O)NC2CCN(Cc3cc(OC(C)C)cc(OC(C)C)c3)CC2)c1

HCID68457139

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID176

Acetic Acid

C2H4O2

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

In analogy to the procedure described in example 50k), crude rac-3-(2,3-dihydroxy-propoxy)-5-methoxy-N-piperidin-4-yl-benzamide trifluoroacetate was reacted with 3,5-diisopropoxy-benzaldehyde (example 126b), sodium cyanoborohydride, N-ethyl-diisopropylamine and acetic acid in ethanol at 50° C. to yield the title compound as colorless amorphous solid. MS: 531.3 (MH+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-492981eeb3c9498380dc3350bc6ad699
来源数据集: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07772253B2
来源说明: uspto-grants-2010_08

反应 SMILES

FC(F)(F)C(O)=O.[OH:8][CH:9]([CH2:29][OH:30])[CH2:10][O:11][C:12]1[CH:13]=[C:14]([CH:24]=[C:25]([O:27][CH3:28])[CH:26]=1)[C:15]([NH:17][CH:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1)=[O:16].[CH:31]([O:34][C:35]1[CH:36]=[C:37]([CH:40]=[C:41]([O:43][CH:44]([CH3:46])[CH3:45])[CH:42]=1)[CH:38]=O)([CH3:33])[CH3:32].C([BH3-])#N.[Na+].C(N(C(C)C)C(C)C)C>C(O)C.C(O)(=O)C>[OH:8][CH:9]([CH2:29][OH:30])[CH2:10][O:11][C:12]1[CH:13]=[C:14]([CH:24]=[C:25]([O:27][CH3:28])[CH:26]=1)[C:15]([NH:17][CH:18]1[CH2:23][CH2:22][N:21]([CH2:38][C:37]2[CH:40]=[C:41]([O:43][CH:44]([CH3:46])[CH3:45])[CH:42]=[C:35]([O:34][CH:31]([CH3:33])[CH3:32])[CH:36]=2)[CH2:20][CH2:19]1)=[O:16]