Diisopropylethylamine → HCID 68456944, 화합물

HRID 502453노트

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HRID 502453 반응식
[CH3:1][O:2][C:3](=[O:35])[C:4]1[CH:32]=[C:31]([O:33][CH3:34])[CH:30]=[C:6]([C:7]([NH:9][CH:10]2[CH2:15][CH2:14][N:13](CC3C=C(OCC)C(F)=C(OCC)C=3)[CH2:12][CH2:11]2)=[O:8])[CH:5]=1.[CH2:36]([O:38][C:39]1[CH:44]=[C:43]([CH:45]=O)[CH:42]=[C:41]([O:47][CH2:48][CH3:49])[C:40]=1[C:50]1[CH:55]=[CH:54][C:53]([F:56])=[CH:52][CH:51]=1)[CH3:37].C([BH3-])#N.[Na+].C(N(C(C)C)C(C)C)C>C(O)C.C(O)(=O)C>[CH3:1][O:2][C:3](=[O:35])[C:4]1[CH:32]=[C:31]([O:33][CH3:34])[CH:30]=[C:6]([C:7]([NH:9][CH:10]2[CH2:11][CH2:12][N:13]([CH2:45][C:43]3[CH:44]=[C:39]([O:38][CH2:36][CH3:37])[C:40]([C:50]4[CH:55]=[CH:54][C:53]([F:56])=[CH:52][CH:51]=4)=[C:41]([O:47][CH2:48][CH3:49])[CH:42]=3)[CH2:14][CH2:15]2)=[O:8])[CH:5]=1

참가 물질

7

반응물 4

HCID 81531DiisopropylethylamineHCID 5003444Sodium cyanoborohydrideHCID 593831002,6-Diethoxy-4'-fluoro-biphenyl-4-carbaldehydeHCID 68458070N-[1-(3,5-Diethoxy-4-fluoro-benzyl)-piperidin-4-yl]-5-methoxy-isophthalamic acid methyl ester

생성물 1

HCID 68456944HCID 68456944, 화합물

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 702Ethanol용매

실험 절차

In analogy to the procedure described in example 50k), 5-methoxy-N-piperidin-4-yl-isophthalamic acid methyl ester (example 143) was reacted with 2,6-diethoxy-4′-fluoro-biphenyl-4-carbaldehyde (example 102), sodium cyanoborohydride, N-ethyl-diisopropylamine and acetic acid in ethanol at 50° C. to yield the title compound as off-white solid. MS: 565.3 (MH+).

출처 및 근거

ORD 기록
ord-ef942b6e00f74fe8b87d28e18419856f
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772253B2

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