HRID502458

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81531

Diisopropylethylamine

C8H19N

HCID5003444

Sodium cyanotrihydroborate

CH3BNNa

HCID59383100

未命名化合物

结构：CCOc1cc(CN2CCC(NC(=O)c3cc(OC)cc(OCC(O)CO)c3)CC2)cc(OCC)c1Cl

HCID68455978

未命名化合物

PRODUCTS

生成物

结构：CCOc1cc(CN2CCC(NC(=O)c3cc(OC)cc(OCC(O)CO)c3)CC2)cc(OCC)c1-c1ccc(F)cc1

HCID68454650

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID176

Acetic Acid

C2H4O2

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

In analogy to the procedure described in example 50k), rac-3-(2,3-dihydroxy-propoxy)-5-methoxy-N-piperidin-4-yl-benzamide hydrochloride (example 248) was reacted with 2,6-diethoxy-4′-fluoro-biphenyl-4-carbaldehyde (example 102), sodium cyanoborohydride, N-ethyl-diisopropylamine and acetic acid in ethanol at 50° C. to yield the title compound as colorless solid. MS: 597.3 (MH+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6e87a855f1ec40c9a9dd626004630266
来源数据集: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07772253B2
来源说明: uspto-grants-2010_08

反应 SMILES

Cl[C:2]1[C:31]([O:32][CH2:33][CH3:34])=[CH:30][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH:13][C:14](=[O:29])[C:15]3[CH:20]=[C:19]([O:21][CH3:22])[CH:18]=[C:17]([O:23][CH2:24][CH:25]([OH:28])[CH2:26][OH:27])[CH:16]=3)[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:35][CH2:36][CH3:37].C(OC1C=C(C=O)C=C(OCC)C=1[C:52]1[CH:57]=[CH:56][C:55]([F:58])=[CH:54][CH:53]=1)C.C([BH3-])#N.[Na+].C(N(C(C)C)C(C)C)C>C(O)C.C(O)(=O)C>[CH2:36]([O:35][C:3]1[CH:4]=[C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH:13][C:14](=[O:29])[C:15]3[CH:20]=[C:19]([O:21][CH3:22])[CH:18]=[C:17]([O:23][CH2:24][CH:25]([OH:28])[CH2:26][OH:27])[CH:16]=3)[CH2:9][CH2:8]2)[CH:30]=[C:31]([O:32][CH2:33][CH3:34])[C:2]=1[C:52]1[CH:57]=[CH:56][C:55]([F:58])=[CH:54][CH:53]=1)[CH3:37]