反应详情

Ringopening polymerization of lactide (L-lactide for system (A) and D-lactide for system B, each 5 g) was carried out using 2-(2-methoxyethoxy)ethanol (MEE, 0.556 g) as an initiator, and stannous octoate (0.093 g) as the catalyst. The polymerization was carried out in the melt at 130° C. for four hours to yield MEE-L-lactic acid oligomer (A) and MEE-D-lactic acid oligomer (B). FIG. 1 shows the reaction scheme for the synthesis of dex-lactate (8), in which the DP is the degree of polymerization and DS is the degree of substitution (number of lactic acid oligomers per 100 glucopyranose units of dextran.