Isopropylamine → n-Isopropyl-5-phenylfuro[2,3-d]pyrimidin-4-amine

HRID 502637Notes

Reaction equation

HRID 502637 reaction equation
Cl[C:2]1[C:3]2[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[CH:9][O:8][C:4]=2[N:5]=[CH:6][N:7]=1.[CH:17]([NH2:20])([CH3:19])[CH3:18]>C(O)(C)C>[CH:17]([NH:20][C:2]1[C:3]2[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[CH:9][O:8][C:4]=2[N:5]=[CH:6][N:7]=1)([CH3:19])[CH3:18]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 594278334-Chloro-5-phenylfuro[2,3-d]pyrimidine

Product 1

HCID 58603278n-Isopropyl-5-phenylfuro[2,3-d]pyrimidin-4-amine

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Into a 50 mL round bottom flask was placed 4-chloro-5-phenylfuro[2,3-d]pyrimidine, isopropanol (25 mL), and isopropylamine (1.5 g, 25 mmol). The flask was equipped with a magnetic stir bar, a reflux condenser, and argon balloon and the reaction was brought to reflux with stirring for 20 hours.

Workup

  1. customInto a 50 mL round bottom flask was placed
  2. customThe flask was equipped with a magnetic stir bar, a reflux condenser
  3. temperatureto reflux

Sources & evidence

ORD record
ord-f0d5b5a96a7b4505810185840659879b
Source dataset
uspto-grants-2010_08
Patent number
US07776867B2

Reaction notes

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