反应详情

温度

80 °C

A mixture of 1-(3-chloropropoxy)-4-nitrobenzene (2 g, 9.27 mmol), potassium carbonate (7.69 g, 46.4 mmol) and acetonitrile (15 ml) was prepared and stirred in a tube. To the stirring solution dimethylamine hydrochloride (3.78 g, 46.4 mmol) was added quickly. The tube was sealed and the mixture was stirred while heating overnight at 80° C. The mixture was cooled well before opening the pressure tube, then water and dichloromethane were added and the aqueous layer was extracted with dichloromethane. The combined organics were dried and evaporated giving the title product.

1. customwas prepared
2. customThe tube was sealed
3. stirringthe mixture was stirred
4. temperatureThe mixture was cooled well
5. extractionthe aqueous layer was extracted with dichloromethane
6. customThe combined organics were dried
7. customevaporated