Ethanol → 2-Methyl-2-(2-thienyl)propanohydrazide

HRID 502947Notes

Reaction equation

HRID 502947 reaction equation
O.[NH2:2][NH2:3].C(O)C.[CH3:7][C:8]([C:15]1[S:16][CH:17]=[CH:18][CH:19]=1)([CH3:14])[C:9](OCC)=[O:10].C(OCC)(=O)C>O>[CH3:7][C:8]([C:15]1[S:16][CH:17]=[CH:18][CH:19]=1)([CH3:14])[C:9]([NH:2][NH2:3])=[O:10]

Participants

6

Reactant 4

HCID 702EthanolHCID 8857Ethyl AcetateHCID 24654Hydrazine hydrate (1:1)HCID 21099804Ethyl 2-methyl-2-(thiophen-2-yl)propanoate

Product 1

HCID 684672282-Methyl-2-(2-thienyl)propanohydrazide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
70 °C

Procedure

Hydrazine monohydrate (2.6 ml) was added to an ethanol (10 ml) solution of ethyl 2-methyl-2-(2-thienyl)propanoate (530 mg), followed by stirring at 70° C. for 48 hours. After the reaction solution and ethyl acetate were added to water, the organic layer was separated. Furthermore, the organic layer washed with saturated brine and, after drying over anhydrous sodium sulfate and filtration, the solvent was removed by evaporation under reduced pressure to obtain 447 mg of 2-methyl-2-(2-thienyl)propanohydrazide (colorless oil).

Workup

  1. customthe organic layer was separated
  2. washFurthermore, the organic layer washed with saturated brine
  3. dry with materialafter drying over anhydrous sodium sulfate and filtration
  4. customthe solvent was removed by evaporation under reduced pressure

Sources & evidence

ORD record
ord-f2d9600b8fef4ae08d1d12d2e70eb7b7
Source dataset
uspto-grants-2010_08
Patent number
US07776897B2

Reaction notes

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