Methyl iodide → Methyl 1-(2-thienyl)cyclobutanecarboxylate

HRID 502953Notes

Reaction equation

HRID 502953 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1([C:10]([OH:12])=[O:11])[CH2:9][CH2:8][CH2:7]1.CI.[C:15](=O)([O-])O.[K+]>CN(C=O)C>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1([C:10]([O:12][CH3:15])=[O:11])[CH2:7][CH2:8][CH2:9]1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 516893Potassium BicarbonateHCID 232948871-Thien-2-ylcyclobutanecarboxylic acid

Product 1

HCID 68467379Methyl 1-(2-thienyl)cyclobutanecarboxylate

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1-(2-Thienyl)cyclobutanecarboxylic acid, methyl iodide, and potassium hydrogen carbonate were reacted in DMF at room temperature to obtain methyl 1-(2-thienyl)cyclobutanecarboxylate.

Sources & evidence

ORD record
ord-37af93649fd14a9aa76e4450f00e6ffd
Source dataset
uspto-grants-2010_08
Patent number
US07776897B2

Reaction notes

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