Hydrazine hydrate (1:1) → HCID 68471002, compound

HRID 502958Notes

Reaction equation

HRID 502958 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1([C:12](Cl)=[O:13])[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1.O.[NH2:16][NH2:17]>C1COCC1>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1([C:12]([NH:16][NH2:17])=[O:13])[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 242296654-(Thiophen-2-yl)oxane-4-carbonyl chloride

Product 1

HCID 68471002HCID 68471002, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

4-(2-Thienyl)tetrahydropyran-4-carboxylic acid was reacted with thionyl chloride and a catalytic amount of DMF in methylene chloride under heating to obtain 4-(2-thienyl)tetrahydropyran-4-carbonyl chloride. A THF solution of 4-(2-thienyl)tetrahydropyran-4-carbonyl chloride was added dropwise to a THF solution of hydrazine monohydrate and the whole was reacted at 0° C. to obtain 4-(2-thienyl)tetrahydropyran-4-carbohydrazide.

Workup

  1. customthe whole was reacted at 0° C.

Sources & evidence

ORD record
ord-61c01869d20c4aae908b3ae0f132abcd
Source dataset
uspto-grants-2010_08
Patent number
US07776897B2

Reaction notes

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