4-Hydroxybenzoic Acid → HCID 28390708, compound

HRID 502965Notes

Reaction equation

HRID 502965 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([OH:10])=O)=[CH:4][CH:3]=1.CCN=C=N[CH2:16][CH2:17][CH2:18][N:19](C)C.Cl.C1C=C2N=NN(O)C2=CC=1.O.C1(N)CC1>CN(C=O)C>[CH:18]1([NH:19][C:8](=[O:10])[C:5]2[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][CH:6]=2)[CH2:16][CH2:17]1

Participants

6

Reactant 4

HCID 1354-Hydroxybenzoic AcidHCID 69828CyclopropylamineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 27960291-Hydroxybenzotriazole hydrate

Product 1

HCID 28390708HCID 28390708, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4-Hydroxybenzenecarboxylic acid was stirred with WSC hydrochloride, HOBt hydrate and cyclopropylamine in DMF at room temperature to obtain N-cyclopropyl-4-hydroxybenzamide.

Sources & evidence

ORD record
ord-37b9b8097f6c4770882f37bb2093a153
Source dataset
uspto-grants-2010_08
Patent number
US07776897B2

Reaction notes

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