Hydrochloric Acid → HCID 86616226, compound

HRID 502979Notes

Reaction equation

HRID 502979 reaction equation
[Cl:1][C:2]1[C:6]([CH3:7])=[CH:5][S:4][C:3]=1[C:8]1([C:13]([NH:15][NH:16][C:17](=[S:20])[NH:18][CH3:19])=O)[CH2:12][CH2:11][CH2:10][CH2:9]1.Cl>[OH-].[Na+]>[Cl:1][C:2]1[C:6]([CH3:7])=[CH:5][S:4][C:3]=1[C:8]1([C:13]2[N:18]([CH3:19])[C:17](=[S:20])[NH:16][N:15]=2)[CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86616225HCID 86616225, compound

Product 1

HCID 86616226HCID 86616226, compoundYield 97.5%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

An 1M aqueous sodium hydroxide solution (10 ml) of 2-{[1-(3-chloro-4-methyl-2-thienyl)cyclopentyl]carbonyl}-N-methylhydrazinecarbothioamide (167 mg) was refluxed for 20 hours. An 1M aqueous hydrochloric acid solution was added to the reaction solution to acidify the solution and precipitated crude crystals were collected by filtration and washed with water to obtain 154 mg of 5-[1-(3-chloro-4-methyl-2-thienyl)cyclopentyl]-4-methyl-2,4-dihydro-3H-1,2,4-triazol-3-thione (pale brown solid).

Workup

  1. customprecipitated crude crystals
  2. filtrationwere collected by filtration
  3. washwashed with water

Sources & evidence

ORD record
ord-6ea1eb924688404ea66998e79c2be115
Source dataset
uspto-grants-2010_08
Patent number
US07776897B2

Reaction notes

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