反应详情

An 1M aqueous sodium hydroxide solution (10 ml) of 2-{[1-(3-chloro-4-methyl-2-thienyl)cyclopentyl]carbonyl}-N-methylhydrazinecarbothioamide (167 mg) was refluxed for 20 hours. An 1M aqueous hydrochloric acid solution was added to the reaction solution to acidify the solution and precipitated crude crystals were collected by filtration and washed with water to obtain 154 mg of 5-[1-(3-chloro-4-methyl-2-thienyl)cyclopentyl]-4-methyl-2,4-dihydro-3H-1,2,4-triazol-3-thione (pale brown solid).

1. customprecipitated crude crystals
2. filtrationwere collected by filtration
3. washwashed with water