Methylamine → HCID 68465430, compound

HRID 503011Notes

Reaction equation

HRID 503011 reaction equation
[NH:1]([C:8]([C:11]1[N:12]([CH3:26])[C:13]([C:16]2[CH:25]=[CH:24][C:19]([C:20](OC)=[O:21])=[CH:18][CH:17]=2)=[N:14][N:15]=1)([CH3:10])[CH3:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[NH2:28]>CO>[NH:1]([C:8]([C:11]1[N:12]([CH3:26])[C:13]([C:16]2[CH:25]=[CH:24][C:19]([C:20]([NH2:28])=[O:21])=[CH:18][CH:17]=2)=[N:14][N:15]=1)([CH3:9])[CH3:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 68465879HCID 68465879, compound

Product 1

HCID 68465430HCID 68465430, compoundYield 121.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 4-[5-(1-anilino-1-methylethyl)-4-methyl-4H-1,2,4-triazol-3-yl}benzoate (300 mg) was dissolved in methanol (1 ml) and then methylamine (30% methanol solution, 886.3 mg) was added thereto, followed by stirring at room temperature overnight. The resulting precipitate was collected by filtration to obtain 349 mg of 4-[5-(1-anilino-1-methylethyl)-4-methyl-4H-1,2,4-triazol-3-yl}benzamide (white crystals).

Workup

  1. filtrationThe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-ec2e2c388208422cbf6e28093920c160
Source dataset
uspto-grants-2010_08
Patent number
US07776897B2

Reaction notes

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