反应详情

Boc-Orn(Boc)-Amp (1.35 g, 3 mmol) was dissolved in EtOAc (200 ml) and to the slightly cloudy solution was added MsOH (0.43 ml, 6.6 mmol) drop wise. The reaction mixture became a clear solution which was stirred at room temperature for approximately 20 hrs. Solvent was removed and the residue was triturated in hexanes. Off-white solid product was formed which was filtered under vacuum and washed with hexanes. The solid was dried in vacuum oven for 20 hrs to obtain 0.88 g of Orn-Amp-2MsOH (l-ornithine-d-amphetamine dimesylate).

1. customSolvent was removed
2. customthe residue was triturated in hexanes
3. customOff-white solid product was formed which
4. filtrationwas filtered under vacuum
5. washwashed with hexanes
6. customThe solid was dried in vacuum oven for 20 hrs