Hydrochloric Acid → HCID 18412630, compound

HRID 50362Notes

Reaction equation

HRID 50362 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([S:11]([N:14]3[CH2:22][C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH2:15]3)(=[O:13])=[O:12])=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:23][NH:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]#[N:32])=[CH:27][CH:26]=1.[ClH:33].C(O)C.C(=O)([O-])[O-].[NH4+:41].[NH4+]>ClCCl.CO>[ClH:33].[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([S:11]([N:14]3[CH2:22][C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH2:15]3)(=[O:12])=[O:13])=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:23][NH:24][C:25]1[CH:26]=[CH:27][C:28]([C:31](=[NH:41])[NH2:32])=[CH:29][CH:30]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 517111Ammonium CarbonateHCID 18412586HCID 18412586, compound

Product 1

HCID 18412630HCID 18412630, compoundYield 33%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared analogously to Example 25d from 1-methyl-2-[N-(4-cyanophenyl)aminomethyl]-5-(isoindolin-2-yl-sulfonyl)benzimidazole and ethanolic hydrochloric acid, ethanol, and ammonium carbonate. Yield: 33% of theory, C24H24N6O2S (460.6); Rf value: 0.32 (silica gel; dichloromethane/methanol=4:1); EKA mass spectrum: (M+H)+=461.

Sources & evidence

ORD record
ord-fd0b2acc5681490d8b660217cf8dea09
Source dataset
uspto-grants-2004_03
Patent number
US06710055B2

Reaction notes

Loading…