反应详情

温度

42.5 °C

A mixture of 130 g of 5-(2-chloroacetyl)-6-chlorooxindole, 455 ml of trifluoroacetic acid and 148.6 g of triethylsilane was maintained at a temperature of about 40-45° C. for 7 hours. The reaction mass was filtered at −5 to 0° C. after maintaining for 1 to 2 hours at the same temperature. The compound was washed with 130 ml of water and further slurried in 650 ml of water. After separation from the water, it was then dried to yield 113 g of the title compound.

1. filtrationThe reaction mass was filtered at −5 to 0° C.
2. temperatureafter maintaining for 1 to 2 hours at the same temperature
3. washThe compound was washed with 130 ml of water and further slurried in 650 ml of water
4. customAfter separation from the water, it
5. customwas then dried