反应详情

75 g of pure ziprasidone base was dissolved in 225 ml of glacial acetic acid at 30° C. 0.75 g of carbon was added to the resulting reaction solution and stirred for 10 minutes at the same temperature. The carbon was filtered and the carbon bed was washed with 7.5 ml of acetic acid. Then the filtrate was added slowly to a mixture of 450 ml ethyl acetate and 99 ml ethyl acetate-hydrochloride (assay 10.57% HCl w/v) at a temperature of 30° C. for 60 min. The reaction mixture was stirred for 1 hour 50 min at the same temperature. The compound was filtered and washed with 185 ml ethyl acetate and dried at a temperature of 90 to 100° C. to afford 80 g of the title compound.

1. addition0.75 g of carbon was added to the resulting reaction solution
2. filtrationThe carbon was filtered
3. washthe carbon bed was washed with 7.5 ml of acetic acid
4. additionThen the filtrate was added slowly to a mixture of 450 ml ethyl acetate and 99 ml ethyl acetate-hydrochloride (assay 10.57% HCl w/v) at a temperature of 30° C. for 60 min
5. stirringThe reaction mixture was stirred for 1 hour 50 min at the same temperature
6. filtrationThe compound was filtered
7. washwashed with 185 ml ethyl acetate
8. customdried at a temperature of 90 to 100° C.