Trifluoroacetic acid → HCID 86617865, compound

HRID 503822Notes

Reaction equation

HRID 503822 reaction equation
C(OC([N:8]1[CH2:13][CH:12]=[C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20](=[O:27])[NH:21][CH2:22][CH2:23][CH:24]3[CH2:26][CH2:25]3)=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH:24]1([CH2:23][CH2:22][NH:21][C:20]([C:17]2[CH:18]=[CH:19][C:14]([C:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH:10]=3)=[N:15][CH:16]=2)=[O:27])[CH2:26][CH2:25]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68463577HCID 68463577, compound

Product 1

HCID 86617865HCID 86617865, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of 5-(2-cyclopropylethylcarbamoyl)-3′,6′-dihydro-2′H-[2,4′]bipyridinyl-1′-carboxylic acid tert-butyl ester (0.338 g, 0.910 mmol) in dichloromethane (10 mL) was added trifluoroacetic acid (0.7 mL). The resulting mixture was stirred at room temperature for 6 hours and then quenched with a saturated aqueous solution of Na2CO3 (5 mL). The organic phase was washed with water (10 mL), saturated NaCl (10 mL), dried over MgSO4 and then concentrated in vacuo. The crude title compound was obtained and used without further purification.

Workup

  1. customquenched with a saturated aqueous solution of Na2CO3 (5 mL)
  2. washThe organic phase was washed with water (10 mL), saturated NaCl (10 mL)
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-1b4c16e13cb740168879a512d5d355fa
Source dataset
uspto-grants-2010_08
Patent number
US07777036B2

Reaction notes

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